Preorbital carcinoma in two Kirk's dik-diks (Madoqua kirkii)

J Comp Pathol. 2013 May;148(4):414-8. doi: 10.1016/j.jcpa.2012.08.005. Epub 2012 Oct 9.

Abstract

Two Kirk's dik-diks suffered from chronic, unilateral, therapy-resistant enlargement of the preorbital gland. Computed tomographic imaging revealed a homogenous preorbital mass destroying the adjacent maxillary bone in one animal. Squamous cell carcinoma was diagnosed microscopically in both cases. Immunohistochemically, the neoplastic cells uniformly expressed cytokeratin (CK) 5/6 and CK14. Additionally, tumour cells were strongly labelled for p53 suggesting a possible role of this tumour suppressor gene in tumorigenesis. Chronic obstruction of the preorbital gland due to excessive accumulation of secretory products is considered as a likely cause of glandular and periglandular inflammation with subsequent malignant transformation.

Publication types

  • Case Reports

MeSH terms

  • Animals
  • Antelopes*
  • Carcinoma, Squamous Cell / genetics
  • Carcinoma, Squamous Cell / pathology
  • Carcinoma, Squamous Cell / veterinary*
  • Cell Transformation, Neoplastic / genetics
  • Exocrine Glands / pathology*
  • Soft Tissue Neoplasms / genetics
  • Soft Tissue Neoplasms / pathology
  • Soft Tissue Neoplasms / veterinary*