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Structure. 2012 Oct 10;20(10):1611-2. doi: 10.1016/j.str.2012.09.002.

Dynein: a force (generation mechanism) to be reckoned with.

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  • 1Institute of Structural and Molecular Biology, Birkbeck College, London WC1E 7HX, UK. c.moores@mail.cryst.bbk.ac.uk

Abstract

In this issue of Structure, Roberts et al. discuss how cryo-electron microscopy single particle reconstructions of the microtubule-based motor dynein reveal dramatic nucleotide-dependent conformational changes. They provide insight into dynein force generation and hint at shared mechanisms with other AAA+ unfoldases.

PMID:
23063004
DOI:
10.1016/j.str.2012.09.002
[PubMed]
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