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Bioinformatics. 2012 Dec 15;28(24):3169-77. doi: 10.1093/bioinformatics/bts605. Epub 2012 Oct 11.

Tools for mapping high-throughput sequencing data.

Author information

1
EMBL Outstation, European Bioinformatics Institute (EBI), Hinxton, Cambridge CB10 ISD, UK. nf@ebi.ac.uk

Abstract

MOTIVATION:

A ubiquitous and fundamental step in high-throughput sequencing analysis is the alignment (mapping) of the generated reads to a reference sequence. To accomplish this task, numerous software tools have been proposed. Determining the mappers that are most suitable for a specific application is not trivial.

RESULTS:

This survey focuses on classifying mappers through a wide number of characteristics. The goal is to allow practitioners to compare the mappers more easily and find those that are most suitable for their specific problem.

PMID:
23060614
DOI:
10.1093/bioinformatics/bts605
[Indexed for MEDLINE]

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