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Anticancer Res. 2012 Oct;32(10):4467-71.

Diffusion-weighted MRI and PSA correlations in patients with prostate cancer treated with radiation and hormonal therapy.

Author information

1
Department of Radiology, Graduate School of Medical science, University of the Ryukyus, 207 Uehara, Nishihara-cho, Okinawa 903-0215, Japan. irayu@med.u-ryukyu.ac.jp

Abstract

AIM:

To investigate the correlation between signal intensity (SI) on diffusion-weighted imaging (DWI) and the levels of prostate-specific antigen (PSA) in patients with prostate cancer treated with radiation and hormonal therapy.

PATIENTS AND METHODS:

Forty-four patients with prostate cancer treated with hormonal therapy and radiation therapy were evaluated. Areas with high SI on DWI were detected and the apparent diffusion co-efficient (ADC) values were measured. The ADC values and PSA levels were compared between patients with high-DWI SI and patients with a normal DWI signal.

RESULTS:

Fourteen patients had high SI on DWI. The mean ADC value in these cancerous lesions was lower than in non-cancerous tissues. The mean PSA level in patients with high-DWI SI was significantly higher than in patients with a normal signal.

CONCLUSION:

The present results suggest that SI on DWI appears to correlate with PSA levels in patients with prostate cancer treated with radiation and hormonal therapy.

PMID:
23060574
[Indexed for MEDLINE]

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