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Int J Bioinform Res Appl. 2012;8(5-6):342-65. doi: 10.1504/IJBRA.2012.049621.

Estimation of sleepiness using pupillary response and its frequency components.

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Human System Science, Graduate School of Decision Science and Technology, Tokyo Institute of Technology, Ookayama, Meguro, Tokyo 152-8552, Japan.


Pupillary response has been used as an index of sleepiness, but the validity of the index is not clear. In this paper, the influence of blinks on the Pupillary Unrest Index (PUI) and the Power Spectrum Density (PSD) as indices of pupil instability during a sleepiness test was examined. To create pupillary indices for sleepiness, four frequency components of the compensated pupillary change were extracted from PSD. These factor components were applied to two-class classifications of subjective sleepiness using discriminant analysis, and their performance was assessed. Differences in contribution ratios for the four factor components were observed between the two kinds of subjective sleepiness. Finally, a causal path diagram was created to show the relationship between blink, pupillary indices and subjective sleepiness.

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