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Gut Microbes. 2013 Jan-Feb;4(1):54-9. doi: 10.4161/gmic.22429. Epub 2012 Oct 12.

Ras-oncogenic Drosophila hindgut but not midgut cells use an inflammation-like program to disseminate to distant sites.

Author information

1
Department of Bbiological Sciences, University of Cyprus, Nicosia, Cyprus.

Abstract

The gastrointestinal tract is habitable by a variety of microorganisms and it is often a tissue inflicted by inflammation. Much discussion is raised in recent years about the role of microbiota in intestinal inflammation, but their role in intestinal cancer remains unclear. Here we discuss and extent our work on Drosophila melanogaster models of tumorigenesis and tumor cell invasion upon intestinal infection. In Drosophila midgut bacteria that cause enterocyte damage induce intestinal stem cell proliferation, which is diverted toward aberrant stem cell expansion upon oncogene expression to induce dysplastic tumors. In the hindgut though, oncogenes synergize with the innate immune response-not the bacterially mediated damage-to induce tumor cell invasion and dissemination to distant sites. Interestingly, our novel gene expression analysis of Drosophila hemocyte-like cells suggests commonalities with oncogenic hindgut cells in the innate immune response and the expression of matrix metalloproteinase 1 in response to bacterial infection.

KEYWORDS:

Drosophila; bacteria; cancer; hindgut; inflammation; innate immune response; microbiota; midgut

PMID:
23060054
PMCID:
PMC3555887
DOI:
10.4161/gmic.22429
[Indexed for MEDLINE]
Free PMC Article

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