Format

Send to

Choose Destination
See comment in PubMed Commons below
RNA Biol. 2012 Dec;9(12):1491-7. doi: 10.4161/rna.22358. Epub 2012 Oct 11.

Type I toxin-antitoxin systems in Bacillus subtilis.

Author information

1
CNRS UPR 9073 (affiliated with Univ. Paris Diderot, Sorbonne Paris Cité), Institut de Biologie Physico-Chimique, Paris, France.

Abstract

Type I toxin-antitoxin (TA) systems are widespread in bacteria and consist of a toxin-encoding mRNA and a partially overlapping antisense RNA that blocks expression of the toxin, either at the level of translation or by mRNA degradation. Four type I toxin families have so far been proposed in B. subtilis based on sequence similarity: TxpA/BsrG, BsrH/BsrE, YonT and YhzE and two (TxpA and BsrG) have been studied in some detail. Here we review what is known about these confirmed and putative toxin-antitoxin families in B. subtilis, their regulatory mechanisms, their potential roles and how they may link to the physiology of the cell.

KEYWORDS:

RNA degradation; antisense RNA; antitoxins; post-segregational killing; prophage; toxins

PMID:
23059907
DOI:
10.4161/rna.22358
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Taylor & Francis
    Loading ...
    Support Center