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J Glaucoma. 2014 Mar;23(3):164-8. doi: 10.1097/IJG.0b013e31826a7dea.

Lipocalin-like prostaglandin D synthase (L-PGDS) concentration in aqueous humour in patients with open-angle glaucoma.

Author information

1
Departments of *Ophthalmology §Laboratory Medicine, Kantonsspital Aarau, Aarau †Eye Clinic, University Hospital of Zurich, Zurich ‡Eye Institute, University of Basel, Basel, Switzerland.

Abstract

PURPOSE:

To report on the concentration of lipocalin-like prostaglandin D synthase (L-PGDS) in the aqueous humour (AH) in patients with open-angle glaucoma (OAG).

PATIENTS AND METHODS:

Prospective assessment in 20 patients (13 female, 7 male, mean age 74±10.6 y) who underwent surgery for OAG. AH was sampled and analyzed for L-PGDS concentration. AH from 26 patients (11 female, 15 male, 72.4±14.4 y) without glaucoma who underwent cataract surgery, served as control subjects.

RESULTS:

The L-PGDS concentration in the AH sampled from the anterior chamber in the OAG group (5.9±2.4 mg/L) was significantly (P<0.001) higher than in the control group (3.3±1.3 mg/L). There were no significant differences between the concentrations of L-PGDS between the left and the right eye or between genders.

CONCLUSIONS:

L-PGDS concentration in the AH of patients with OAG was significantly elevated compared with its concentration in the AH of nonglaucomatous eyes. As L-PGDS is a biologically pluripotent protein, its possible role in glaucoma warrants further examination.

PMID:
23059482
DOI:
10.1097/IJG.0b013e31826a7dea
[Indexed for MEDLINE]
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