Format

Send to

Choose Destination
See comment in PubMed Commons below
Trends Parasitol. 2012 Dec;28(12):539-45. doi: 10.1016/j.pt.2012.09.002. Epub 2012 Oct 8.

Trypanosome resistance to human innate immunity: targeting Achilles' heel.

Author information

1
Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA.

Abstract

Trypanosome lytic factors (TLFs) are powerful, naturally occurring toxins in humans that provide sterile protection against infection by several African trypanosomes. These trypanocidal complexes predominantly enter the parasite by binding to the trypanosome haptoglobin/hemoglobin receptor (HpHbR), trafficking to the lysosome, causing membrane damage and, ultimately, cell lysis. Despite TLF-mediated immunity, the parasites that cause human African Trypanosomiasis (HAT), Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense, have developed independent mechanisms of resistance to TLF killing. In this review we describe the parasite defenses that allow trypanosome infections of humans and discuss how targeting these apparent strengths of the parasite may reveal their Achilles' heel, leading to new approaches in the treatment of HAT.

PMID:
23059119
PMCID:
PMC4687903
DOI:
10.1016/j.pt.2012.09.002
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center