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J Ethnopharmacol. 2012 Dec 18;144(3):775-8. doi: 10.1016/j.jep.2012.09.033. Epub 2012 Oct 8.

Diuretic activity of the ethanol and aqueous extracts of the surface layer of Poria cocos in rat.

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1
Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Sciences, Northwest University, No. 229 Taibai North Road, Xi'an, Shaanxi 710069, PR China. zyy@nwu.edu.cn

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE:

Poria cocos Wolf (Polyporaceae) is a well-known traditional East-Asian medicinal fungus. the epidermis ("Fu-Ling-Pi" in Chinese) of the sclerotia is used as a diuretic. This study was conducted to evaluate of ethanol extract (EE) and aqueous extract (AE) of the diuretic activity of Fu-Ling-Pi in saline-loaded rats.

MATERIAL AND METHODS:

The EE and AE were orally administered to rats. Urinary excretion rate, pH and electrolyte excretion were measured in the urine of saline-loaded rats.

RESULTS:

Urinary excretion rates were significantly increased by the EE. The three doses of AE only produced a slight increase urinary output. The EE had little or no effect on K(+) excretion, but did indeed induce a notable excretion of Na(+), that was in agreement with the urinary excretion. The three doses of AE produced an increase Na(+) and K(+) excretion, but did not arrive at statistical significance.

CONCLUSIONS:

The present study confirmed that the not aqueous but ethanol extracts of the epidermis of Poria cocos presents a remarkable diuretic effect.

PMID:
23058989
DOI:
10.1016/j.jep.2012.09.033
[Indexed for MEDLINE]
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