Format

Send to

Choose Destination
See comment in PubMed Commons below
PLoS One. 2012;7(10):e46232. doi: 10.1371/journal.pone.0046232. Epub 2012 Oct 3.

Evaluation of the efficacy of excimer laser ablation of cross-linked porcine cornea.

Author information

1
Affiliated Eye Hospital of Wenzhou Medical College, Lucheng District, Wenzhou, Zhejiang, People's Republic of China.

Abstract

BACKGROUND:

Combination of riboflavin/UVA cross-linking (CXL) and excimer laser ablation is a promising therapy for treating corneal ectasia. The cornea is strengthened by cross-linking, while the irregular astigmatism is reduced by laser ablation. This study aims to compare the efficacy of excimer laser ablation on porcine corneas with and without cross-linking.

METHODS AND FINDINGS:

The porcine cornea was de-epithelialized and treated with 0.1% riboflavin solution for 30 minutes. A half of the cornea was exposed to UVA-radiation for another 30 minutes while the controlled half of the cornea was protected from the UVA using a metal shield. Photo therapeutic keratectomy (PTK) was then performed on the central cornea. Corneal thickness of 5 paired locations on the horizontal line, ± 0.5, ± 1.0, ± 1.5, ± 2.0, and ± 2.5 mm from the central spot, were measured using optical coherence tomography prior to and after PTK. The ablation depth was then determined by the corneal thickness. There was a 9% difference (P<0.001) in the overall ablation depth between the CXL-half corneas (158 ± 22 µm) and the control-half corneas (174 ± 26 µm). The ablation depths of all 5 correspondent locations on the CXL-half were significantly smaller (P<0.001).

CONCLUSION:

The efficacy of the laser ablation seems to be lower in cross-linked cornea. Current ablation algorithms may need to be modified for cross-linked corneas.

PMID:
23056269
PMCID:
PMC3463596
DOI:
10.1371/journal.pone.0046232
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Public Library of Science Icon for PubMed Central
    Loading ...
    Support Center