Format

Send to

Choose Destination
See comment in PubMed Commons below
PLoS Genet. 2012;8(10):e1002947. doi: 10.1371/journal.pgen.1002947. Epub 2012 Oct 4.

The date of interbreeding between Neandertals and modern humans.

Author information

1
Department of Genetics, Harvard Medical School, Boston, MA, USA. sankararaman@genetics.med.harvard.edu

Abstract

Comparisons of DNA sequences between Neandertals and present-day humans have shown that Neandertals share more genetic variants with non-Africans than with Africans. This could be due to interbreeding between Neandertals and modern humans when the two groups met subsequent to the emergence of modern humans outside Africa. However, it could also be due to population structure that antedates the origin of Neandertal ancestors in Africa. We measure the extent of linkage disequilibrium (LD) in the genomes of present-day Europeans and find that the last gene flow from Neandertals (or their relatives) into Europeans likely occurred 37,000-86,000 years before the present (BP), and most likely 47,000-65,000 years ago. This supports the recent interbreeding hypothesis and suggests that interbreeding may have occurred when modern humans carrying Upper Paleolithic technologies encountered Neandertals as they expanded out of Africa.

PMID:
23055938
PMCID:
PMC3464203
DOI:
10.1371/journal.pgen.1002947
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Public Library of Science Icon for PubMed Central
    Loading ...
    Support Center