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Onco Targets Ther. 2012;5:245-53. doi: 10.2147/OTT.S35958. Epub 2012 Oct 1.

Helical tomotherapy provides efficacy similar to that of intensity-modulated radiation therapy with dosimetric benefits for endometrial carcinoma.

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1
Division of Radiation Oncology, Department of Radiology, Far Eastern Memorial Hospital, New Taipei City ; Department of Medicine, National Yang-Ming University ; Institute of Traditional Medicine, School of Medicine, National Yang-Ming University ; Oriental Institute of Technology, New Taipei City.

Abstract

BACKGROUND:

The purpose of this study was to compare the efficacy of intensity-modulated radiotherapy (IMRT) and helical tomotherapy for endometrial cancer.

METHODS:

Between November 1, 2006 and November 31, 2010, 31 patients with histologically confirmed endometrial cancer were enrolled. All enrolled patients received total abdominal hysterectomy and bilateral salpingo-oophorectomy with adjuvant whole pelvic IMRT or helical tomotherapy.

RESULTS:

The actuarial 3-year overall survival, disease-free survival, locoregional control, and distant metastasis-free rates for the IMRT and helical tomotherapy groups were 87.5% versus 100%, 91.7% versus 51.7%, 91.7% versus 83.3%, and 91.7% versus 51.7%, respectively. The conformal index and uniformity index for IMRT versus helical tomotherapy was 1.25 versus 1.17 (P = 0.04) and 1.08 versus 1.05 (P < 0.01), respectively. Two of 31 patients with cervical stump failure were noted, one in the IMRT group and the other in the helical tomotherapy group. No acute or late grade 3 or 4 toxicities were noted, including proctitis, or genitourinary or gastrointestinal disturbances.

CONCLUSION:

Helical tomotherapy is as effective as IMRT and has better uniformity and conformal indices, and critical organ-sparing properties. Prospective clinical trials are needed to evaluate the comparative efficacy of IMRT versus helical tomotherapy.

KEYWORDS:

endometrial cancer; helical tomotherapy; intensity-modulated radiotherapy

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