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J Neurosci. 2012 Oct 10;32(41):14118-24. doi: 10.1523/JNEUROSCI.3340-12.2012.

Inhibition of fear by learned safety signals: a mini-symposium review.

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1
Department of Psychology and Neuroscience, University of Colorado, Boulder, Colorado 80309-0345, USA. john.christianson@colorado.edu

Abstract

Safety signals are learned cues that predict the nonoccurrence of an aversive event. As such, safety signals are potent inhibitors of fear and stress responses. Investigations of safety signal learning have increased over the last few years due in part to the finding that traumatized persons are unable to use safety cues to inhibit fear, making it a clinically relevant phenotype. The goal of this review is to present recent advances relating to the neural and behavioral mechanisms of safety learning, and expression in rodents, nonhuman primates, and humans.

PMID:
23055481
PMCID:
PMC3541026
DOI:
10.1523/JNEUROSCI.3340-12.2012
[Indexed for MEDLINE]
Free PMC Article
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