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J Neurosci. 2012 Oct 10;32(41):14058-63. doi: 10.1523/JNEUROSCI.3348-12.2012.

How do short-term changes at synapses fine-tune information processing?

Author information

1
Department of Physiology and Biophysics, University of Colorado School of Medicine, Aurora, Colorado 80045, USA. achim.klug@ucdenver.edu

Abstract

Synaptic transmission is highly dependent on recent activity and can lead to depression or facilitation of synaptic strength. This phenomenon is called "short-term synaptic plasticity" and is shown at all synapses. While much work has been done to understand the mechanisms of short-term changes in the state of synapses, short-term plasticity is often thought of as a mechanistic consequence of the design of a synapse. This review will attempt to go beyond this view and discuss how, on one hand, complex neuronal activity affects the short-term state of synapses, but also how these dynamic changes in synaptic strength affect information processing in return.

PMID:
23055473
PMCID:
PMC3488594
DOI:
10.1523/JNEUROSCI.3348-12.2012
[Indexed for MEDLINE]
Free PMC Article

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