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J Physiol Sci. 2013 Jan;63(1):1-5. doi: 10.1007/s12576-012-0237-4. Epub 2012 Oct 10.

Peroxiredoxins and sports: new insights on the antioxidative defense.

Author information

1
Department of Molecular and Cellular Sport Medicine, German Sport University Cologne, Am Sportpark Müngersdorf 6, 50933, Cologne, Germany. ch.brinkmann@gmx.net.
2
Department of Molecular and Cellular Sport Medicine, German Sport University Cologne, Am Sportpark Müngersdorf 6, 50933, Cologne, Germany.

Abstract

Peroxiredoxins (PRDXs) are multifunctional proteins that have recently received much attention. They are part of the endogenous antioxidative capacity and function as efficient scavengers, especially for hydrogen peroxides. Studies show that physical training can induce an upregulation of PRDX isoform contents in the long term. This might help counteract chronic diseases that are causally linked to a high amount of free radicals, e.g., diabetes mellitus. Furthermore, it has been demonstrated that PRDX can overoxidize under pathological conditions during acute exercise. Overoxidized PRDXs could be useful because they act as protective chaperones. Taken together, it can be speculated that physical activity has a positive effect on the PRDX system and thereby prevents cells from free radical-induced damage.

PMID:
23055024
DOI:
10.1007/s12576-012-0237-4
[Indexed for MEDLINE]
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