Send to

Choose Destination
See comment in PubMed Commons below
Curr Pain Headache Rep. 2012 Dec;16(6):518-24. doi: 10.1007/s11916-012-0299-2.

Neuromuscular function in painful knee osteoarthritis.

Author information

Department of Physical Therapy, University of Illinois at Chicago, 1919 W. Taylor St, 4th floor, Chicago, IL 60612, USA.


Pain is a major cause of impaired mobility in elderly patients with chronic osteoarthritis (OA) of the knee. Central sensitization and impaired nociceptive inhibitory mechanisms have both been identified as contributing factors to heightened pain in this patient population. While central sensitization has been shown to produce enhanced pain responses and spread of pain to adjacent and remote body regions, conditioned pain modulation has also been shown to be adversely affected, and may be characteristic of those patients with chronic pain. Alterations of quantitative sensory testing measures have been demonstrated in patients with knee OA, and may serve as a clinical means of staging chronic musculoskeletal pain, including assessment of hyperalgesia and hypoesthesia. In addition, pain and altered somatosensation commonly associated with OA may be correlated with functional deficits.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer
    Loading ...
    Support Center