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Int J Hematol. 2012 Dec;96(6):810-3. doi: 10.1007/s12185-012-1193-8. Epub 2012 Oct 7.

Two cases of pediatric essential thrombocythemia managed effectively with hydroxyurea.

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Pediatric Hematology Oncology and BMT Unit, Department of Pediatrics Institute of Child Health, Sir Ganga Ram Hospital, Rajender Nagar, New Delhi, 110060, India.


Thrombocytosis is common in infancy and childhood. Essential thrombocythemia (ET), a myeloproliferative disorder, is a much less common cause of thrombocytosis in childhood. We report two cases of essential thrombocythemia in 5- and 10-year-old children, who presented with platelet counts of more than 1,000,000/mm(3). Treatment is not recommended for ET in an asymptomatic patient in the absence of bleeding or thrombosis and a platelet count <1,500,000/mm(3). Our first case had platelets >1,500,000/mm(3), and a second child was symptomatic with recurrent headache. Both responded well to therapy with hydroxyurea (dose 15-30 mg/kg/day) and tolerated it well.

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