Format

Send to

Choose Destination
J Neurochem. 2012 Nov;123 Suppl 2:148-55. doi: 10.1111/j.1471-4159.2012.07953.x.

Activation of immune responses to brain antigens after stroke.

Author information

1
University of Washington School of Medicine, Harborview Medical Center, Seattle, WA, USA. kjb@uw.edu

Abstract

Infection is common after stroke and is independently associated with a worse outcome. The predisposition to infection following stroke is in part related to a sympathetically mediated suppression of the peripheral immune response. The teleological explanation for this immune dysfunction is that it serves to prevent autoimmune responses to brain antigens. We believe that the systemic immune response in patients who develop infection, however, thwarts this seemingly protective response and predisposes to central nervous system autoimmunity. These autoimmune responses may mediate, at least in part, the worse outcome associated with post-stroke infection.

PMID:
23050652
PMCID:
PMC4138833
DOI:
10.1111/j.1471-4159.2012.07953.x
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center