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Exp Diabetes Res. 2012;2012:349320. doi: 10.1155/2012/349320. Epub 2012 Sep 20.

Nicotine exposure exacerbates development of cataracts in a type 1 diabetic rat model.

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1
Department of Ophthalmology and Visual Sciences, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.

Abstract

Diabetes and smoking are known risk factors for cataract development. In this study, we evaluated the effect of nicotine on the progression of cataracts in a type 1 diabetic rat model. Diabetes was induced in Sprague-Dawley rats by a single injection of 65 mg/kg streptozotocin. Daily nicotine injections were administered subcutaneously. Forty-five rats were divided into groups of diabetics with and without nicotine treatment and controls with and without nicotine treatment. Progression of lens opacity was monitored using a slit lamp biomicroscope and scores were assigned. To assess whether systemic inflammation played a role in mediating cataractogenesis, we studied serum levels of eotaxin, IL-6, and IL-4. The levels of the measured cytokines increased significantly in nicotine-treated and untreated diabetic animals versus controls and demonstrated a positive trend in the nicotine-treated diabetic rats. Our data suggest the presence of a synergistic relationship between nicotine and diabetes that accelerated cataract formation via inflammatory mediators.

PMID:
23049540
PMCID:
PMC3459283
DOI:
10.1155/2012/349320
[Indexed for MEDLINE]
Free PMC Article
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