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Chem Commun (Camb). 2012 Nov 25;48(91):11244-6. doi: 10.1039/c2cc36009h. Epub 2012 Oct 9.

Carbenoid-mediated N-O bond insertion and its application in the synthesis of pyridines.

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1
Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 637371, Singapore.

Abstract

Highly efficient synthesis of 3-hydroxypyridines has been developed based on carbenoid-mediated N-O bond insertion. Treatment of δ-diazo oxime ethers with dirhodium complex Rh(2)(tfacam)(4) rapidly provides a variety of pyridines in 5-10 minutes in good to excellent yields.

PMID:
23047585
DOI:
10.1039/c2cc36009h
[Indexed for MEDLINE]
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