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Rev Port Cardiol. 2012 Nov;31(11):733-45. doi: 10.1016/j.repc.2012.02.018. Epub 2012 Oct 6.

[High-sensitivity C-reactive protein as a biomarker of risk in coronary artery disease].

[Article in Portuguese]

Author information

1
Serviço de Cardiologia I, Hospital de Santa Maria, Centro Hospitalar de Lisboa Norte, Lisboa, Portugal. dojreis@hotmail.com

Abstract

Vascular inflammation plays a crucial role in the pathogenesis of atherosclerosis and mediates various stages of atherosclerotic plaque development, from lipid streak formation to the plaque rupture and destabilization that precedes the clinical syndromes of cardiovascular disease. Inflammatory biomarkers constitute valuable tools to study this process, enabling the effects of different therapeutic interventions to be assessed. Currently, C-reactive protein (CRP) determined by high-sensitivity methods (hs-CRP) is the most extensively studied biomarker. Data regarding hs-CRP and cardiovascular risk, though largely consistent, are of unclear clinical relevance. This article provides a comprehensive review of current knowledge concerning cardiovascular risk and hs-CRP, and concludes with an evidence-based analysis of the current role of hs-CRP in cardiovascular risk assessment.

PMID:
23046630
DOI:
10.1016/j.repc.2012.02.018
[Indexed for MEDLINE]
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