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Clin Endocrinol (Oxf). 2013 Jun;78(6):926-34. doi: 10.1111/cen.12068. Epub 2013 Apr 6.

Diabetes and cardiovascular events in women with polycystic ovary syndrome: a 20-year retrospective cohort study.

Author information

1
Department of Cardiovascular Sciences, Leicester Diabetes Centre, University of Leicester, Leicester General Hospital, Leicester, UK. hamidreza.mani@uhl-tr.nhs.uk

Abstract

OBJECTIVE:

Women with polycystic ovary syndrome (PCOS) are potentially at increased risk of cardiovascular (CV) diseases due to well-established risk factors, including insulin resistance, obesity and type 2 diabetes mellitus (T2DM). However, data showing excess CV events in this population are still lacking. We investigated the incidence and prevalence of CV events in a cohort of women with PCOS.

DESIGN:

Retrospective cohort study (total follow-up >12,000 person-years).

SETTING:

Leicester, Leicestershire and Rutland (Total Female population of 434,859), UK.

PARTICIPANTS:

Two thousand three hundred and one women with PCOS (mean age = 29.6 years) attending a speciality clinic in Leicestershire, UK.

MAIN OUTCOMES MEASURES:

T2DM, myocardial infarction (MI), angina, heart failure (HF), stroke and CV-related death.

RESULTS:

Incidence of T2DM, MI, angina, HF, stroke and CV death was respectively 3.6, 0.8, 1.0, 0.3, 0.0 and 0.4 per 1000 person-years. At the end of follow-up, the prevalence of MI in the age groups 45-54, 55-64 and >65 years was 1.9%, 6.0% and 27.3% and of angina was 2.6%, 6.0% and 27.3%, respectively. Age-group-specific odds ratios for the prevalence of MI and angina compared to the local female population ranged between 2.6 (95% CI: 1.0-6.3) and 12.9 (CI: 3.4-48.6) with the highest ratio being for MI in the group >65 years old. Age, history of hypertension and smoking had significant correlations with CV outcomes in the PCOS patients.

CONCLUSION:

We have shown a high incidence and age-group-specific prevalence of T2DM, MI and angina in the women with PCOS, with over a quarter having had MI or angina in those >65 years. These findings should be considered in the treatment strategies and long-term planning for women with PCOS.

Comment in

PMID:
23046078
DOI:
10.1111/cen.12068
[Indexed for MEDLINE]

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