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BMJ Open. 2012 Oct 8;2(5). pii: e001711. doi: 10.1136/bmjopen-2012-001711. Print 2012.

Intensity versus duration of physical activity: implications for the metabolic syndrome. A prospective cohort study.

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Department of Cardiology, Bispebjerg University Hospital, Copenhagen, Denmark.



To explore the relative importance of leisure time physical activity (LTPA), walking and jogging on risk of developing the metabolic syndrome (MS).


A prospective cohort study.


The Copenhagen City Heart Study.


10 135 men and women aged 21-98 years who attended an initial examination in 1991-1994 and were re-examined after 10 years.


The association of LTPA, jogging, walking speed and walking volume with MS at baseline and at 10-year follow-up was investigated by multiple logistic regression analyses.


Baseline prevalence of MS was 20.7% in women and 27.3% in men. In both women and men, MS prevalence was associated with lower LTPA and walking speed and was lower in joggers compared to non-joggers. In subjects free of MS at baseline, 15.4% had developed MS at 10-year follow-up. Risk of developing MS was reduced in subjects with moderate or high LTPA, higher walking speed and in joggers whereas a higher volume of walking was not associated with reduced risk. After multiple adjustment, odds ratio (OR) of developing MS in moderate/high LTPA was 0.71 (95% CI 0.50 to 1.01), fast walking speed 0.51 (0.33 to 0.80) and joggers 0.60 (0.37 to 0.95) and walking >1 h daily 1.22 (0.91 to 1.65).


Our results confirm the role of physical activity in reducing MS risk and suggest that intensity more than volume of physical activity is important.

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