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Nat Rev Genet. 2012 Nov;13(11):807-17. doi: 10.1038/nrg3335. Epub 2012 Oct 9.

Genome-wide association studies in mice.

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1
The Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK.

Abstract

Genome-wide association studies (GWASs) have transformed the field of human genetics and have led to the discovery of hundreds of genes that are implicated in human disease. The technological advances that drove this revolution are now poised to transform genetic studies in model organisms, including mice. However, the design of GWASs in mouse strains is fundamentally different from the design of human GWASs, creating new challenges and opportunities. This Review gives an overview of the novel study designs for mouse GWASs, which dramatically improve both the statistical power and resolution compared to classical gene-mapping approaches.

PMID:
23044826
PMCID:
PMC3625632
DOI:
10.1038/nrg3335
[Indexed for MEDLINE]
Free PMC Article
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