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Cell Res. 2013 Feb;23(2):176-8. doi: 10.1038/cr.2012.142. Epub 2012 Oct 9.

In vitro generation of platelets through direct conversion: first report in My Knowledge (iMK).

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1
Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.

Abstract

Blood transfusion medicine requires a constant supply of platelets, which is now totally donor dependent. Recent advances in the generation of platelets in vitro through megakaryocytes (MKs) may provide protocols not only via pluripotent stem cells, including induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs), but also via induced MKs (iMKs). For the first time, mouse and human fibroblasts are successfully transdifferentiated into iMKs by the introduction of three factors, p45NF-E2, Maf G, and Maf K.

PMID:
23044804
PMCID:
PMC3567822
DOI:
10.1038/cr.2012.142
[Indexed for MEDLINE]
Free PMC Article
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