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Bioorg Med Chem Lett. 2012 Nov 15;22(22):6858-61. doi: 10.1016/j.bmcl.2012.09.036. Epub 2012 Sep 20.

The trifluoromethyl transformation synthesis, crystal structure and insecticidal activities of novel 2-pyrrolecarboxamide and 2-pyrrolecarboxlate.

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1
State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, People's Republic of China.

Abstract

Two series of 2-phenylpyrroles: 3-bromo-5-(4-chlorophenyl)-4-cyanopyrrole-2-carboxamide (5a-5d) and 3-bromo-5-(4-chlorophenyl)-4-cyanopyrrole-2-carboxylate (6a-6c) were synthesized by a novel trifluoromethyl transformation. The result of insecticidal bioassays indicated that 6a-6c had moderate larvicidal activity against oriental armyworm and 6b also had good acaricidal activity, so 3-bromo-5-(4-chlorophenyl)-4-cyanopyrrole-2-carboxylate derivatives were expected to become lead compounds for new pesticides.

PMID:
23044368
DOI:
10.1016/j.bmcl.2012.09.036
[Indexed for MEDLINE]
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