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Bioorg Med Chem Lett. 2012 Nov 15;22(22):6957-61. doi: 10.1016/j.bmcl.2012.08.122. Epub 2012 Sep 21.

Synthesis of 6-amino-2-vinylpurine derivatives for cross-linking and evaluation of the reactivity.

Author information

1
Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai-shi, Miyagi 980-8577, Japan.

Abstract

Oligodeoxynucleotides (ODNs) have been widely used for inhibiting the gene expression in antisense or antigene methods, and the interstrand cross-linking (ICL) forming ODNs have been expected to ensure the inhibition by these methods. Previously, we reported a highly efficient and selective ICL reaction toward cytosine using the 2-amino-6-vinylpurine derivative under acidic conditions. In this Letter, we report the synthesis of ODN containing 6-amino-2-vinylpurine derivatives and evaluation of the cross-linking reactivity.

PMID:
23044366
DOI:
10.1016/j.bmcl.2012.08.122
[Indexed for MEDLINE]

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