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Future Med Chem. 2012 Sep;4(14):1779-89. doi: 10.4155/fmc.12.106.

Ask the experts: the challenges and benefits of flow chemistry to optimize drug development.

Abstract

Against a backdrop of a struggling economic and regulatory climate, pharmaceutical companies have recently been forced to develop new ways to provide more efficient technology to meet the demands of a competitive drug industry. This issue, coupled with an increase in patent legislation and a rising generics market, makes these themes common issues in the growth of drug development. As a consequence, the importance of process chemistry and scale-up has never been more under the spotlight. Future Medicinal Chemistry wishes to share the thoughts and opinions of a variety of experts from this field, discussing issues concerning the use of flow chemistry to optimize drug development, the potential regulatory and environmental challenges faced with this, and whether the academic and industrial sectors could benefit from a more harmonized system relevant to process chemistry.

PMID:
23043475
DOI:
10.4155/fmc.12.106
[Indexed for MEDLINE]
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