Format

Send to

Choose Destination
See comment in PubMed Commons below
Science. 2012 Oct 5;338(6103):60-5. doi: 10.1126/science.1227356.

Theory and simulation in neuroscience.

Author information

1
School of Computer and Communication Sciences and Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland. wulfram.gerstner@epfl.ch

Abstract

Modeling work in neuroscience can be classified using two different criteria. The first one is the complexity of the model, ranging from simplified conceptual models that are amenable to mathematical analysis to detailed models that require simulations in order to understand their properties. The second criterion is that of direction of workflow, which can be from microscopic to macroscopic scales (bottom-up) or from behavioral target functions to properties of components (top-down). We review the interaction of theory and simulation using examples of top-down and bottom-up studies and point to some current developments in the fields of computational and theoretical neuroscience.

PMID:
23042882
DOI:
10.1126/science.1227356
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Support Center