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Cell Biochem Funct. 2013 Jul;31(5):374-9. doi: 10.1002/cbf.2905. Epub 2012 Oct 8.

Hesperetin impairs glucose uptake and inhibits proliferation of breast cancer cells.

Author information

1
Department of Nanomedicine, The Methodist Hospital Research Institute, Houston, TX, USA.

Abstract

The flavanone hesperetin is known to decrease basal glucose uptake, although the inhibitory mechanism is largely unknown. Here, we used MDA-MB-231 breast cancer cells to investigate the molecular pathways affected by hesperetin. The results indicate that the suppression of glucose uptake is caused by the down-regulation of glucose transporter 1 (GLUT1). Hesperetin was also found to inhibit insulin-induced glucose uptake through impaired cell membrane translocation of glucose transporter 4 (GLUT4). In addition, the phosphorylation of the insulin receptor-beta subunit (IR-beta) and Akt was suppressed. Hesperetin also decreased cellular proliferation, which is likely due to the inhibition of glucose uptake. Cancer cells are highly dependent on glucose and hesperetin may, therefore, have potential application as an anticancer agent.

KEYWORDS:

GLUT1; GLUT4; breast cancer cells; glucose uptake; hesperetin

PMID:
23042260
PMCID:
PMC3842231
DOI:
10.1002/cbf.2905
[Indexed for MEDLINE]
Free PMC Article

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