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Cell Immunol. 2012 Sep;279(1):21-4. doi: 10.1016/j.cellimm.2012.08.004. Epub 2012 Sep 14.

T cell subsets and colorectal cancer: discerning the good from the bad.

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1
Institute of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK.

Abstract

Tumor-specific T cells must overcome a multitude of suppressive mechanisms to destroy cancerous cells effectively. Furthermore, it appears that the tumor microenvironment facilitates the development of highly immunosuppressive T cells, which may also allow subsequent tumor progression. In colorectal cancer, the relationship between regulatory T cells (e.g. FoxP3(+) Tregs) and tumor prognosis and progression is less clear, despite their well-documented ability to impinge on anti-tumor immune responses. Here we explore our current knowledge of colorectal TIL heterogeneity, deciphering subsets which may be of benefit or detriment.

PMID:
23041206
DOI:
10.1016/j.cellimm.2012.08.004
[Indexed for MEDLINE]
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