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J Am Acad Dermatol. 2013 Jan;68(1):98-102. doi: 10.1016/j.jaad.2012.05.033. Epub 2012 Oct 2.

1927-nm fractional resurfacing of facial actinic keratoses: a promising new therapeutic option.

Author information

1
Laser & Skin Surgery Center of New York, New York, New York 10016, USA. eweiss@laserskinsurgery.com

Abstract

BACKGROUND:

Actinic keratoses (AK) are precancerous epidermal proliferations commonly present on chronically sun-damaged skin. These lesions are among the most often treated dermatologic conditions.

OBJECTIVE:

We sought to investigate the 6-month safety, tolerance, and efficacy of nonablative 1927-nm fractional resurfacing of facial AK.

METHODS:

This was a prospective clinical trial of 24 individuals with facial photodamage and AK receiving up to 4 treatments with the fractionated 1927-nm nonablative thulium laser.

RESULTS:

At 6 months, an 86.6% reduction in absolute number of lesions was noted by independent physician assessment. In addition, at this same time point, patients reported marked or noticeable improvement in overall photodamage.

LIMITATIONS:

This prospective study does not provide safety, tolerance, and efficacy data beyond 6 months of follow-up, nor does it identify the precise mechanism of action involved in AK clearance after 1927-nm resurfacing.

CONCLUSION:

The clinical and histologic findings, as well as the reported patient satisfaction and safety, suggest that the treatment of AK and photodamage with a fractionated 1927-nm nonablative thulium laser is a promising new therapeutic option.

PMID:
23041112
DOI:
10.1016/j.jaad.2012.05.033
[Indexed for MEDLINE]

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