Format

Send to

Choose Destination
See comment in PubMed Commons below
Neuron. 2012 Oct 4;76(1):82-97. doi: 10.1016/j.neuron.2012.08.035.

Peptide neuromodulation in invertebrate model systems.

Author information

1
Department of Anatomy and Neurobiology, Washington University Medical School, St. Louis, MO 63110, USA. taghertp@pcg.wustl.edu

Abstract

Neuropeptides modulate neural circuits controlling adaptive animal behaviors and physiological processes, such as feeding/metabolism, reproductive behaviors, circadian rhythms, central pattern generation, and sensorimotor integration. Invertebrate model systems have enabled detailed experimental analysis using combined genetic, behavioral, and physiological approaches. Here we review selected examples of neuropeptide modulation in crustaceans, mollusks, insects, and nematodes, with a particular emphasis on the genetic model organisms Drosophila melanogaster and Caenorhabditis elegans, where remarkable progress has been made. On the basis of this survey, we provide several integrating conceptual principles for understanding how neuropeptides modulate circuit function, and also propose that continued progress in this area requires increased emphasis on the development of richer, more sophisticated behavioral paradigms.

PMID:
23040808
PMCID:
PMC3466441
DOI:
10.1016/j.neuron.2012.08.035
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center