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Bioorg Med Chem Lett. 2012 Nov 15;22(22):6919-22. doi: 10.1016/j.bmcl.2012.09.015. Epub 2012 Sep 13.

Viridin analogs derived from steroidal building blocks.

Author information

1
Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT 06269, United States.

Abstract

Naturally occurring furanosteroids such as viridin and wortmannin have long been known as potent inhibitors of the lipid kinase PI-3K. We have been interested in directly accessing analogs of these complex natural products from abundant steroid feedstock materials. In this communication, we describe the synthesis of viridin/wortmannin hybrid molecules from readily available building blocks that function as PI-3K inhibitors and maintain their electrophilic properties. The compounds also show anti-proliferative effects against a breast cancer line.

PMID:
23040731
DOI:
10.1016/j.bmcl.2012.09.015
[Indexed for MEDLINE]

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