Format

Send to

Choose Destination
Angew Chem Int Ed Engl. 2012 Oct 29;51(44):11014-8. doi: 10.1002/anie.201205831. Epub 2012 Oct 4.

Click and pick: identification of sialoside analogues for siglec-based cell targeting.

Author information

1
Department of Chemical Physiology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA.

Abstract

Click 'n' chips: Azide and alkyne-bearing sialic acids (purple diamond; see picture) were subjected to high-throughput click chemistry to generate a library of sialic acid analogues. Microarray printing of the library and screening with the siglec family of sialic-acid-binding proteins, led to the identification of high-affinity ligands for siglec-9 and siglec-10.

PMID:
23038623
PMCID:
PMC3480989
DOI:
10.1002/anie.201205831
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center