Format

Send to

Choose Destination
Mov Disord. 2012 Oct;27(12):1559-63. doi: 10.1002/mds.25127. Epub 2012 Oct 4.

Bilateral subthalamic nucleus stimulation for generalized dystonia after bilateral pallidotomy.

Author information

1
Division of Functional Neurosurgery, Department of Neurology of School of Medicine of University of São Paulo, São Paulo SP, Brazil. fonoffet@usp.br

Abstract

BACKGROUND:

Thalamotomies and pallidotomies were commonly performed before the deep brain stimulation (DBS) era. Although ablative procedures can lead to significant dystonia improvement, longer periods of analysis reveal disease progression and functional deterioration. Today, the same patients seek additional treatment possibilities.

METHODS:

Four patients with generalized dystonia who previously had undergone bilateral pallidotomy came to our service seeking additional treatment because of dystonic symptom progression. Bilateral subthalamic nucleus DBS (B-STN-DBS) was the treatment of choice. The patients were evaluated with the Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS) and the Unified Dystonia Rating Scale (UDRS) before and 2 years after surgery.

RESULTS:

All patients showed significant functional improvement, averaging 65.3% in BFMDRS (P = .014) and 69.2% in UDRS (P = .025).

CONCLUSIONS:

These results suggest that B-STN-DBS may be an interesting treatment option for generalized dystonia, even for patients who have already undergone bilateral pallidotomy.

PMID:
23038611
DOI:
10.1002/mds.25127
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center