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Bioorg Med Chem Lett. 2012 Nov 15;22(22):6980-5. doi: 10.1016/j.bmcl.2012.06.002. Epub 2012 Aug 30.

N,N-Dimethyl-[9-(arylsulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl]amines as novel, potent and selective 5-HT₆ receptor antagonists.

Author information

1
Discovery Research, Suven Life Sciences Ltd, Serene Chambers, Road-5, Avenue-7, Banjara Hills, Hyderabad 500 034, India. ramakrishna_nirogi@yahoo.co.in

Abstract

The design, synthesis and SAR of novel tetrahydrocarbazole derivatives having 5-HT(6) receptor antagonist activity is presented. The racemic compound 15e was found to possess desirable pharmacokinetic properties, adequate brain penetration and activity in animal models of cognition.

PMID:
23036955
DOI:
10.1016/j.bmcl.2012.06.002
[Indexed for MEDLINE]

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