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Acta Biomater. 2013 Feb;9(2):4956-63. doi: 10.1016/j.actbio.2012.09.035. Epub 2012 Oct 2.

Inflammatory cell response to calcium phosphate biomaterial particles: an overview.

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EA 4691 Biomatériaux et Inflammation en Site Osseux-BIOS, SFR CAP-Santé-FED 4231, Université de Reims-Champagne-Ardenne, UFR Odontologie, CHU de Reims, 1 Avenue du Maréchal Juin, 51095 Reims Cedex, France.


Bone is a metabolically active and highly organized tissue consisting of a mineral phase of hydroxyapatite (HA) and amorphous calcium phosphate (CaP) crystals deposited in an organic matrix. One objective of bone tissue engineering is to mimic the chemical and structural properties of this complex tissue. CaP ceramics, such as sintered HA and beta-tricalcium phosphate, are widely used as bone substitutes or prosthesis coatings because of their osteoconductive properties. These ceramic interactions with tissues induce a cell response that can be different according to the composition of the material. In this review, we discuss inflammatory cell responses to CaP materials to provide a comprehensive overview of mechanisms governing the integration or loosening of implants, which remains a major concern in tissue engineering. A focus on the effects of the functionalization of CaP biomaterials highlights potential ways to increase tissue integration and limit rejection processes.

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