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J Allergy Clin Immunol. 2012 Nov;130(5):1030-48. doi: 10.1016/j.jaci.2012.07.049. Epub 2012 Oct 1.

Warts and all: human papillomavirus in primary immunodeficiencies.

Author information

1
Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-1684, USA. jleiding@health.usf.edu

Abstract

Infection with human papillomavirus (HPV) is almost universal and eventually asymptomatic, but pathologic infection with HPV is severe, recurrent, and recalcitrant to therapy. It is also an underappreciated manifestation of primary immunodeficiency. Mutations in EVER1, EVER2, GATA2, CXCR4, and dedicator of cytokinesis 8 (DOCK8) are typically associated with extensive HPV infections, whereas several other primary immune defects result in severe HPV much less frequently. We review immunodeficiencies with severe HPV infections and the mechanisms underlying them.

PMID:
23036745
PMCID:
PMC3517887
DOI:
10.1016/j.jaci.2012.07.049
[Indexed for MEDLINE]
Free PMC Article

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