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FEBS Lett. 2012 Nov 2;586(21):3825-30. doi: 10.1016/j.febslet.2012.09.032. Epub 2012 Oct 1.

Stimulation of Escherichia coli DNA damage inducible DNA helicase DinG by the single-stranded DNA binding protein SSB.

Author information

1
Department of Biological Sciences, Louisiana State University, Baton Rouge, LA 70803, USA.

Abstract

Escherichia coli DNA damage inducible protein DinG is a superfamily II DNA helicase and is closely related to human DNA helicase XPD. Here, we report that E. coli single-stranded DNA binding protein (SSB) is able to form a stable protein complex with DinG and to stimulate the DinG DNA helicase activity. An SSB mutant that retains the single-stranded DNA binding activity but fails to form a protein complex with DinG becomes a potent inhibitor for the DinG DNA helicase, suggesting that E. coli wild-type SSB stimulates the DinG DNA helicase via specific protein-protein interaction.

PMID:
23036643
PMCID:
PMC3483465
DOI:
10.1016/j.febslet.2012.09.032
[Indexed for MEDLINE]
Free PMC Article
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