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J Clin Pharmacol. 1990 Jan;30(1):39-44.

Effect of concurrent sucralfate administration on the absorption of erythromycin.

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Department of Family Medicine, Baylor College of Medicine, Houston, TX 77005.


To determine the influence of sucralfate on the absorption of erythromycin, prior to evaluating its efficacy in decreasing erythromycin-associated gastrointestinal (GI) intolerance, we assessed pharmacokinetic parameters in six healthy adult volunteers. Erythromycin ethylsuccinate administered alone or with sucralfate as a single dose was compared. Sucralfate did not significantly alter the elimination rate constant, half-life, or area under the curve for erythromycin ethylsuccinate. It is therefore unlikely that efficacy of erythromycin ethylsuccinate will be altered when sucralfate is coadministered.

[Indexed for MEDLINE]

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