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J Virol. 2012 Dec;86(24):13779-84. doi: 10.1128/JVI.01625-12. Epub 2012 Oct 3.

Distribution and dynamics of transcription-associated proteins during parvovirus infection.

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  • 1Nanoscience Center, Department of Biological and Environmental Science, University of Jyväskylä, Finland.

Abstract

Canine parvovirus (CPV) infection leads to reorganization of nuclear proteinaceous subcompartments. Our studies showed that virus infection causes a time-dependent increase in the amount of viral nonstructural protein NS1 mRNA. Fluorescence recovery after photobleaching showed that the recovery kinetics of nuclear transcription-associated proteins, TATA binding protein (TBP), transcription factor IIB (TFIIB), and poly(A) binding protein nuclear 1 (PABPN1) were different in infected and noninfected cells, pointing to virus-induced alterations in binding dynamics of these proteins.

PMID:
23035221
PMCID:
PMC3503060
DOI:
10.1128/JVI.01625-12
[PubMed - indexed for MEDLINE]
Free PMC Article
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