A) *1*: Mean EPSC of the dlPFC model (red), overlaying the representative EPSC recorded empirically from dlPFC neurons (black, from ). *2*: Mean EPSC of the V1 model, using the same *ḡ*_{AMPA} as the dlPFC model (*left*, blue dotted line), and when reducing *ḡ*_{AMPA} by 69% (*right*, blue solid line). Model traces overlay the representative EPSC recorded empirically from V1 neurons (grey, from ). *3*: Normalized overlay of mean EPSC traces of the dlPFC and low *ḡ*_{AMPA} V1 models. B) *Left*, EPSC amplitude vs. synaptic distance from the soma in the dlPFC model (red filled circles) and V1 model (blue open circles), assuming equal values of *g*_{AMPA}. Right, log-transformed EPSC amplitudes versus synaptic distance from the soma. The best-fit linear regression of log(amplitude) vs. distance is shown in black. C) Cumulative frequency histograms of EPSC amplitudes in the dlPFC and low-*ḡ*_{AMPA} V1 models (1 pA bins; filled red circles and open blue circles respectively). Cumulative frequency histograms of the dlPFC (black line) and V1 (grey line) empirical data are superimposed. D) EPSCs evoked by activation of each individual synapse on the apical and basal arbors, for the dlPFC and low-*ḡ*_{AMPA} V1 models. Individual EPSCs shown in black; mean EPSC traces shown in color. E) Bar graphs comparing kinetics of EPSCs in dlPFC vs. low-*ḡ*_{AMPA} V1 model neurons.

Scale bars: A, 5 pA/20 ms; D, 5 pA/10 ms. ***p* < 0.01.

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