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Nat Cell Biol. 2012 Oct;14(10):983-5. doi: 10.1038/ncb2598.

Connecting membrane traffic to ESCRT and the final cut.

Abstract

The ESCRT (endosomal sorting complex required for transport) machinery is responsible for scission of the cytokinetic bridge that connects daughter cells at the end of mitosis. Specific endosomes are now found to mediate local bridge constriction and actin clearance in human cells, which contribute to the recruitment of ESCRT components at the abscission site.

PMID:
23033048
DOI:
10.1038/ncb2598
[Indexed for MEDLINE]

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