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Hum Genet. 1990 Feb;84(3):249-52.

Increased frequency of 6-thioguanine-resistant peripheral blood lymphocytes in Werner syndrome patients.

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1
Department of Medicine and Geriatrics, Osaka University Medical School, Japan.

Abstract

The frequency of spontaneous 6-thioguanine (TG)-resistant peripheral blood lymphocytes in five unrelated Werner syndrome (WS) patients was determined using an autoradiographic labeling assay. The average frequency of TG-resistant lymphocytes was eightfold higher in WS patients than in sex- and age-matched normal control donors. This finding and previous identification of increased spontaneous chromosomal rearrangements and deletions in WS cells or cell lines suggest that WS is a human genomic instability or mutator syndrome.

PMID:
2303247
[Indexed for MEDLINE]
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