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AIDS. 2012 Nov 28;26(18):2409-12. doi: 10.1097/QAD.0b013e32835a9950.

Increased coronary atherosclerosis and immune activation in HIV-1 elite controllers.

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1
Program in Nutritional Metabolism, Department of Radiology, Massachusetts General Hospital, Boston, USA.

Abstract

HIV-1 elite controllers spontaneously maintain suppressed levels of viremia, but exhibit significant immune activation. We investigated coronary atherosclerosis by coronary computed tomography angiography (CTA) in elite controllers, nonelite controller, chronically HIV-1 infected, antiretroviral therapy (ART)-treated patients with undetectable viral load ('chronic HIV'), and HIV-negative controls. Prevalence of atherosclerosis (78 vs. 42%, P < 0.05) and markers of immune activation were increased in elite controllers compared with HIV-negative controls. sCD163, a monocyte activation marker, was increased in elite controllers compared with chronic HIV-1 (P < 0.05) and compared with HIV-negative controls (P < 0.05). These data suggest a significant degree of coronary atherosclerosis and monocyte activation among elite controllers.

PMID:
23032411
PMCID:
PMC3660105
DOI:
10.1097/QAD.0b013e32835a9950
[Indexed for MEDLINE]
Free PMC Article
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