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Phys Rev E Stat Nonlin Soft Matter Phys. 2012 Sep;86(3 Pt 1):031916. Epub 2012 Sep 17.

Mathematical modeling of genome replication.

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  • 1Centre for Genetics and Genomics, University of Nottingham, Nottingham NG7 2UH, United Kingdom.

Abstract

Eukaryotic DNA replication is initiated from multiple sites on the chromosome, but little is known about the global and local regulation of replication. We present a mathematical model for the spatial dynamics of DNA replication, which offers insight into the kinetics of replication in different types of organisms. Most biological experiments involve average quantities over large cell populations (typically >10(7) cells) and therefore can mask the cell-to-cell variability present in the system. Although the model is formulated in terms of a population of cells, using mathematical analysis we show that one can obtain signatures of stochasticity in individual cells from averaged quantities. This work generalizes the result by Retkute et al. [Phys. Rev. Lett. 107, 068103 (2011)] to a broader set of parameter regimes.

PMID:
23030953
PMCID:
PMC3671344
DOI:
10.1103/PhysRevE.86.031916
[PubMed - indexed for MEDLINE]
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