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Orbit. 2012 Oct;31(5):324-6. doi: 10.3109/01676830.2011.584932.

Methotrexate as an alternative treatment for orbital angiolymphoid hyperplasia with eosinophilia.

Author information

1
Department of Ophthalmology and Visual Sciences University of Iowa Hospitals and Clinics, Iowa City, IA, USA.

Abstract

Angiolymphoid hyperplasia with eosinophilia (ALHE) is an uncommon, benign disorder that presents as solitary or multiple nodules in the dermis or subcutaneous tissue. Orbital ALHE has been reported on occasion. We report a case of orbital ALHE which was refractory to systemic steroids but effectively treated with low-dose subcutaneous methotrexate. To our knowledge, this is the first reported case of methotrexate as a successful treatment for refractory ALHE.

PMID:
23030406
DOI:
10.3109/01676830.2011.584932
[Indexed for MEDLINE]

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