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PLoS One. 2012;7(9):e46486. doi: 10.1371/journal.pone.0046486. Epub 2012 Sep 28.

The polyoma virus large T binding protein p150 is a transcriptional repressor of c-MYC.

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1
Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, United States of America.

Abstract

p150, product of the SALL2 gene, is a binding partner of the polyoma virus large T antigen and a putative tumor suppressor. p150 binds to the nuclease hypersensitive element of the c-MYC promoter and represses c-MYC transcription. Overexpression of p150 in human ovarian surface epithelial cells leads to decreased expression, and downregulation to increased expression, of c-MYC. c-MYC is repressed upon restoration of p150 to ovarian carcinoma cells. Induction of apoptosis by etoposide results in recruitment of p150 to the c-MYC promoter and to repression of c-MYC. Analysis of data in The Cancer Genome Atlas shows negative correlations between SALL2 and c-MYC expression in four common solid tumor types.

PMID:
23029531
PMCID:
PMC3460914
DOI:
10.1371/journal.pone.0046486
[Indexed for MEDLINE]
Free PMC Article
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